By Anthony E. Redington, Alyn H. Morice
A accomplished assessment of the clinical and medical points of acute and protracted cough, this reference specializes in fresh advancements in our figuring out of the molecular biology of putative cough receptors, the neural mechanisms thinking about the afferent and efferent limbs, the principal processing of the cough reflex, and peptides and different elements that can mediate or modulate the cough reflex. With chapters wriitenby stated gurus within the box, this guide covers present and strength healing brokers, quite a few methodologies to degree cough reflex sensitivity, and scientific methods for the review of continual cough in adults and kids.
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Extra resources for Acute and Chronic Cough (Lung Biology in Health and Disease, Volume 205)
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The axons of C-fibers conducting nociceptive signals are unmyelinated and their cell bodies are small in size. Their peripheral terminals are specialized to detect painful (nociceptive) stimuli such as heat, mechanical insults, and inflammatory mediators, and are also referred to as nociceptors (4). Vagal C-fibers initiate bronchoconstriction and some types of cough reflex (5,6), and are closely involved in key aspects of airway diseases associated with hypersensitivity (2,7). The application of nociceptive stimuli to the airways results in excitation of airway C-fiber afferents leading to the subsequent release of tachykinins and neuropeptides from the fibers, thus causing local effects including smooth muscle contraction (8).
The complex and intriguing lives of PIP2 with ion channels and transporters. Sci STKE 2001; 2001:RE19. 85. Minke B, Cook B. TRP channel proteins and signal transduction. Physiol Rev 2002; 82:429–472. 86. Caterina MJ, Leffler A, Malmberg AB, Martin WJ, Trafton J, Petersen-Zeitz KR, Koltzenburg M, Basbaum AI, Julius D. Impaired nociception and pain sensation in mice lacking the capsaicin receptor. Science 2000; 288:306–313. 87. Davis JB, Gray J, Gunthorpe MJ, Hatcher JP, Davey PT, Overend P, Harries MH, Latcham J, Clapham C, Atkinson K, Hughes SA, Rance K, Grau E, Harper AJ, Pugh PL, Rogers DC, Bingham S, Randall A, Sheardown SA.
Acute and Chronic Cough (Lung Biology in Health and Disease, Volume 205) by Anthony E. Redington, Alyn H. Morice