Airway Smooth Muscle in Asthma and COPD: Biology and - download pdf or read online

By Kian Fan Chung

ISBN-10: 0470060662

ISBN-13: 9780470060667

During this publication, best researchers in medication and molecular pharmacology clarify the mobile mechanisms that regulate airway delicate muscle. The ability through which those are disrupted in affliction, and the pharmacologic ideas through which they're transformed are mentioned and destiny healing interventions are identified. Aimed at experts in pulmonology, this quantity offers the clinician with the hottest details on one of many middle physiological tactics in airway sickness, and provides insights into present and destiny methods to management. Authoritative replace on key mechanisms of airway constriction in bronchial asthma and COPDRelates most modern learn to bronchodilator therapyMulti-contributed textual content, co-coordinated via of the prime experts within the box.

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Extra info for Airway Smooth Muscle in Asthma and COPD: Biology and Pharmacology

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1995). Airway hyperresponsiveness in asthma: a problem of limited smooth muscle relaxation with inspiration. J Clin Invest 96, 2393–2403. Small, J. V. (1995). Structure–function relationships in smooth muscle: the missing links. Bioessays 17, 785–792. Small, J. V. and Gimona, M. (1998). The cytoskeleton of the vertebrate smooth muscle cell. Acta Physiol Scand 164, 341–348. Smith, B. , Martin, J. G. et al. (2005). Probing the viscoelastic behavior of cultured airway smooth muscle cells with atomic force microscopy: stiffening induced by contractile agonist.

The limit of resolution in our system is on the order of ∼10 nm, but for t ∼ 4 s most beads had displaced a much greater distance. Accordingly, we analysed data for time lags greater than 4 s and up to tmax . As shown below, MSD of most beads increases with time according to a power-law relationship. MSD( t) = D ∗ ( t/ to )␣ (2) The coefficient D ∗ and the exponent ␣ of an individual bead are estimated from a least-square fit of a power-law to the MSD data for t between 4 s and tmax /4. Here we take to to be 1 s and express D ∗ in units of nm2 .

And Hall, I. P. (2001). Effects of growth factors and extracellular matrix on survival of human airway smooth muscle cells. Am J Respir Cell Mol Biol 25, 569–576. Freyer, A. , Billington, C. , Penn, R. B. et al. (2004). Extracellular matix modulates ␤2 -adrenergic receptor signaling in human airway smooth muscle cells. Am J Respir Cell Mol Biol 31, 440–445. Gerthoffer, W. T. and Pohl, J. (1994). Caldesmon and calponin phosphorylation in regulation of smooth muscle contraction. Can J Physiol Pharmacol 72, 1410–1414.

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Airway Smooth Muscle in Asthma and COPD: Biology and Pharmacology by Kian Fan Chung

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