By David A Bender(auth.)
Amino Acid Metabolism, 3rd Edition covers all features of the biochemistry and dietary biochemistry of the amino acids. beginning with an summary of nitrogen fixation and the incorporation of inorganic nitrogen into amino acids, the ebook then info different significant nitrogenous compounds in micro-organisms, vegetation and animals. Contents comprise a dialogue of the catabolism of amino acids and different nitrogenous compounds in animals, and the microbiological reactions interested by unencumber of nitrogen gasoline again into the ambience. Mammalian (mainly human) protein and amino acid requisites are thought of intimately, and the equipment which are used to figure out them.
Chapters think of person amino acids, grouped in accordance with their metabolic starting place, and discussing their biosynthesis (in crops and micro-organisms for those who are nutritional necessities for human beings), significant metabolic roles (mainly in human metabolism) and catabolism (again quite often in human metabolism). there's additionally dialogue of regulatory mechanisms for these types of metabolic pathways, and of metabolic and genetic illnesses affecting the (human) metabolism of amino acids.
Throughout the booklet the emphasis is at the dietary value of amino acids, integration and keep watch over of metabolism and metabolic and different disturbances of relevance to human biochemistry and health.
- Completely revised version of this accomplished textual content overlaying all of the most modern findings in amino acid metabolism research
- Written by means of an expert within the box
- Covers new advances in structural biology
- Clear illustrations of all buildings and metabolic pathways
- Full checklist of advised extra studying for every bankruptcy and bibliography of papers stated within the text
Chapter 1 Nitrogen Metabolism (pages 1–65):
Chapter 2 Nitrogen stability and Protein Turnover – Protein and Amino Acids in Human foodstuff (pages 67–104):
Chapter three The function of diet B6 in Amino Acid Metabolism (pages 105–128):
Chapter four Glycine, Serine and the One?Carbon Pool (pages 129–155):
Chapter five Amino Acids Synthesized from Glutamate: Glutamine, Proline, Ornithine, Citrulline and Arginine (pages 157–223):
Chapter 6 Amino Acids Synthesized from Aspartate: Lysine, Methionine (and Cysteine), Threonine and Isoleucine (pages 225–277):
Chapter 7 The Branched?Chain Amino Acids: Leucine, Isoleucine and Valine (pages 279–303):
Chapter eight Histidine (pages 305–322):
Chapter nine The fragrant Amino Acids: Phenylalanine, Tyrosine and Tryptophan (pages 323–376):
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Additional info for Amino Acid Metabolism, Third Edition
As a result of the inhibition of ribonucleotide reductase, there is failure to synthesize the other deoxynucleotides needed for DNA synthesis. , 1978). 4 THE SYNTHESIS AND CATABOLISM OF PURINE AND PYRIMIDINE NUCLEOTIDES 35 own bone marrow in vitro, and then transplanting them back into the patient. , 2010; Silver & Flotte, 2008). 2 Gout and hyperuricaemia Gout is a painful inﬂammatory condition caused by crystallization of uric acid salts in joints, as nodules under the skin, and sometimes in the kidney, leading to kidney failure, as a result of a blood concentration that is above the low solubility product of uric acid and its salts.
It is a molybdenum-containing ﬂavoprotein with two iron-sulphur centres. The reaction involves reduction of MoVI to MoIV by transfer of electrons from the substrate, followed by electron transfer to the ﬂavin via the iron-sulphur centres and reduction of oxygen to hydrogen peroxide. Xanthine oxidase can be converted to xanthine dehydrogenase, which reduces NAD+ rather than 32 CHAPTER 1 NITROGEN METABOLISM oxygen, by formation of disulphide bridges catalyzed by glutathionedependent thiol disulphide oxidoreductase.
When both adenylosuccinate synthetase and IMP dehydrogenase are inhibited by their end products) is rapidly dephosphorylated to inosine by phosphomonoesterase, followed by the action of purine nucleotide phosphorylase to yield hypoxanthine. GMP in excess of requirements is also a substrate for phosphomonoesterase and purine nucleotide phosphorylase, yielding guanine, which is deaminated to xanthine. AMP in excess of requirements is a substrate for AMP deaminase, yielding IMP, or may be a substrate for phosphomonoesterase, liberating adenosine, which is deaminated by adenosine deaminase.
Amino Acid Metabolism, Third Edition by David A Bender(auth.)