By Johannes Ring
Anaphylaxis is the main dramatic and in all likelihood life-threatening manifestation of an immediate-type allergy response. even though identified for over a hundred years, it nonetheless poses many unresolved questions, and its sensible administration and acute remedy are frequently extra empiric in nature than evidence-based. during this publication, a multidisciplinary workforce of specialists overview the state-of-the-art within the pathophysiology, epidemiology, prognosis and medical symptomatology of anaphylaxis. Its etiology in regards to varied elicitors akin to insect venoms, radiocontrast media, analgesics, common and native anesthetics is tested intimately. ultimately, therapy modalities for anaphylaxis are mentioned either for acute reactions and as normal administration techniques for sufferers in danger. delivering thorough and updated insurance of this often underestimated challenge, this booklet is of curiosity not just to allergologists and immunologists, but additionally to all physicians and affected sufferers.
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Extra info for Anaphylaxis (Chemical Immunology and Allergy, Vol. 95)
30 Pavek K, Wegmann A, Nordström L, Schwander D: Cardiovascular and respiratory mechanisms in anaphylactic and anaphylactoid shock reactions. Klin Wochenschr 1982;60:941–947. 31 Pumphrey RS: Lessons for management of anaphylaxis from a study of fatal reactions. Clin Exp Allergy 2000;30:1144–1150. 32 Ludolph-Hauser D, Ruëff F, Przybilla B: Diagnose und Differentialdiagnose der Anaphylaxie; in Schultze-Werninghaus G, Fuchs T, Bachert C, Wahn U (eds): Manuale allergologicum, 3. , München, Dustri, 2008, pp 669–685.
Epidemiological reviews indicate that penicillins  and insect stings are still the most frequent causes of anaphylaxis . Rare cases of passive transfer by IgE antibodies via blood transfusion have been described as well as attempted suicide (penicillin-allergic nurse). In belletristic literature, murder attempts by eliciting anaphylaxis can be found. Also a psychosomatic condition ‘anaphylaxis factitita’ exists in the sense of Münchhausen’s syndrome. When no elicitor can be found, the term ‘idiopathic’ anaphylaxis is used [2, 16, 35, 40, 50].
Early detection of the responsible allergen is a requisite and an important prognostic factor in controlling allergic diseases and anaphylaxis . Dendritic cells (DCs) are complex cell populations that differ in their anatomic location, antigen recognition, processing machinery, and migratory capacity. DCs stay as sentinels that take up exogenous antigens and transmit the information into immune system by migrating to draining lymph nodes, and presenting the processed antigens to T cells resulting in T-cell differentiation and activation [7, 8].
Anaphylaxis (Chemical Immunology and Allergy, Vol. 95) by Johannes Ring