Download e-book for iPad: Antigen Processing and Presentation Protocols by Jill R. Beyette, Timothy Hubbell (auth.), Joyce C. Solheim

By Jill R. Beyette, Timothy Hubbell (auth.), Joyce C. Solheim (eds.)

ISBN-10: 0896037452

ISBN-13: 9780896037458

ISBN-10: 1592590624

ISBN-13: 9781592590629

The processing and presentation of antigens by way of significant histocompatibility complicated (MHC) molecules is a vital immunological phenomenon in infectious disorder, malignancy, autoimmune disorder, and transplantation. In Antigen Processing and Presentation Protocols, well-recognized and cutting edge experimentalists aspect their state-of-the-art equipment for learning this advanced technique. Drawing on services from biochemistry, telephone biology, and immunology, they describe step by step tools designed to question how MHC-binding peptides are generated, to check how peptides are brought to MHC molecules, to investigate MHC peptide-binding styles, and to assay the T telephone reaction to the MHC/peptide advanced. each one approach is gifted in enough element to be simply reproducible and comprises notes approximately power pitfalls and the best way to stay away from disasters. Emphasis is given these technical steps severe for experimental good fortune which are usually passed over from tools released within the basic literature.
Eminently obtainable and state of the art, Antigen Processing and Presentation Protocols offers either new and skilled investigators with hugely sensible instruments that might expand the questions that may be requested, and successfully be spoke back, touching on antigen processing/presentation.

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34, 1–32. 3. Yewdell, J. W. and Bennink, J. R. (1992) Cell biology of antigen processing and presentation to Major Histocompatibility Complex class I molecule-restricted T lymphocytes. Adv. Immunol. 52, 1–123. 4. Goldberg, A. L. and Rock, K. L. (1992) Proteolysis, proteasomes and antigen processing. Nature 357, 375-379. 5. , and Monaco, J. J. (1998) How do endogenous proteins become peptides and reach the endoplasmic reticulum. Curr. Top. Microbiol. Immunol. 232, 15–47. 6. Rock, K. , and Goldberg, A.

Eur. J. Biochem. 255, 356–362. Hershko, A. and Ciechanover, A. (1998) The ubiquitin system. Ann. Rev. Biochem. 67, 425–479. Grimm, L. M. and Osborne, B. A. (1999) Apoptosis and the proteasome. Results Probl. Cell Differ. 23, 209–228. Meriin, A. , Gabai, V. , Shifrin, V. , and Sherman, M. Y. (1998) Proteasome inhibitors activate stress kinases and induce Hsp72. Diverse effects on apoptosis. J. Biol. Chem. 273, 6373–6379. Yellen-Shaw, A. J. C. (1997) Regulation of class I-restricted epitope processing by local or distal flanking sequence.

36. Moore, M. , Carbone, F. , and Bevan, M. J. (1988) Introduction of soluble protein into the class I pathway of antigen processing and presentation. Cell 54, 777–785. 37. Dick, L. , Cruikshank, A. , Destree, A. , McCormack, T. , Melandri, F. , et al. (1997) Mechanistic studies on the inactivation of the proteasome by lactacystin in cultured cells. J. Biol. Chem. 272, 182–188. Peptides and MHC-I in Ag Presentation 33 3 Tracing the Route Taken by Peptides and Major Histocompatibility Complex Class I Molecules in Presentation of Exogenous Antigens Christopher C.

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Antigen Processing and Presentation Protocols by Jill R. Beyette, Timothy Hubbell (auth.), Joyce C. Solheim (eds.)

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